All posts by rbuchan

Publication in Nature Communications!

Guangbo’s work on an intriguing new role for Endocytic function in facilitating clearance of TDP-43 aggregates, which are implicated in ALS pathology, is now published. Thanks to our collaborators including several members of the Zarnescu Lab (Alyssa Coyne, Spencer Vaughn, Mathew Chaung) and Fen Pei of the Serio lab.

Guangbo and Clayton publish in PLOS One

Guangbo and Clayton, together with expert help from Matt Kaplan, have published a technical protocol paper in PLOS One. The paper describes a high-throughput robotic method that allows yeast researchers to transform and genetically modify > 1000 yeast strains in a day. Congrats Guangbo and Clayton!

Nichole’s paper published in RNA!

Our first “proper” paper is out in RNA – “Defects in THO/TREX-2 function cause accumulation of novel cytoplasmic mRNP granules that can be cleared by autophagy”.  Well done Nichole, Guangbo and Kaitlyn!

Starter grant award from ALSA

We are happy to announce that the Buchan lab has been awarded a starter grant from the Amyotrophic Lateral Sclerosis Association.  This 1 year grant ($40k) will be focused on the effects of Granulophagy on clearance of ALS inclusion bodies, which share many properties in common with stress granules.