Publications

.Kunkel J, Luo X, Kaplan ME, & Capaldi AP (2019) Integrated TORC1 and PKA signaling control the temporal activation of glucose-induced gene expression in yeast.  Nature Communications. https://doi.org/10.1038/s41467-019-11540-y 

Sullivan A, Wallace RL, Wellington, R, Luo X & Capaldi AP (2018) Multi-layered regulation of TORC1-body formation in budding yeast.  MBoC. https://doi.org/10.1091/mbc.E18-05-0297

Worley J, Sullivan A, Luo X, Kaplan ME, & Capaldi AP (2015) Genome-Wide Analysis of the TORC1 and Osmotic Stress Signaling Network in Saccharomyces cerevisiae. G3 (Bethesda) 6(2):463-474. pdf

Hughes Hallett JE, Luo X, & Capaldi AP (2015) Snf1/AMPK promotes the formation of Kog1/Raptor-bodies to increase the activation threshold of TORC1 in budding yeast. Elife 4. pdf

Hughes Hallett JE, Luo X, & Capaldi AP (2014) State transitions in the TORC1 signaling pathway and information processing in Saccharomyces cerevisiae. Genetics 198(2):773-786. pdf

Worley J, Luo X, & Capaldi AP (2013) Inositol pyrophosphates regulate cell growth and the environmental stress response by activating the HDAC Rpd3L. Cell Reports 3(5):1476-1482. pdf

Buchan JR, Capaldi AP, & Parker R (2012) TOR-tured yeast find a new way to stand the heat. Mol Cell 47(2):155-157. pdf

Capaldi AP (2010) Analysis of gene function using DNA microarrays. Methods Enzymol 470:3-17. pdf

Capaldi AP, et al. (2008) Structure and function of a transcriptional network activated by the MAPK Hog1. Nat Genet 40(11):1300-1306. pdf

Spence GR, Capaldi AP, & Radford SE (2004) Trapping the on-pathway folding intermediate of Im7 at equilibrium. J Mol Biol 341(1):215-226.

Gorski SA, et al. (2004) Equilibrium hydrogen exchange reveals extensive hydrogen bonded secondary structure in the on-pathway intermediate of Im7. J Mol Biol 337(1):183-193.

Friel CT, Capaldi AP, & Radford SE (2003) Structural analysis of the rate-limiting transition states in the folding of Im7 and Im9: similarities and differences in the folding of homologous proteins. J Mol Biol 326(1):293-305.

Capaldi AP, Kleanthous C, & Radford SE (2002) Im7 folding mechanism: misfolding on a path to the native state. Nat Struct Biol 9(3):209-216.

Gorski SA, Capaldi AP, Kleanthous C, & Radford SE (2001) Acidic conditions stabilise intermediates populated during the folding of Im7 and Im9. J Mol Biol 312(4):849-863.

Ferguson N, Li W, Capaldi AP, Kleanthous C, & Radford SE (2001) Using chimeric immunity proteins to explore the energy landscape for alpha-helical protein folding. J Mol Biol 307(1):393-405.

Capaldi AP, Shastry MC, Kleanthous C, Roder H, & Radford SE (2001) Ultrarapid mixing experiments reveal that Im7 folds via an on-pathway intermediate. Nat Struct Biol 8(1):68-72.

Jones S, et al. (2000) Partially unfolded species populated during equilibrium denaturation of the beta-sheet protein Y74W apo-pseudoazurin. Biochemistry 39(19):5672-5682.

Ferguson N, Capaldi AP, James R, Kleanthous C, & Radford SE (1999) Rapid folding with and without populated intermediates in the homologous four-helix proteins Im7 and Im9. J Mol Biol 286(5):1597-1608.

Capaldi AP, Ferguson SJ, & Radford SE (1999) The Greek key protein apo-pseudoazurin folds through an obligate on-pathway intermediate. J Mol Biol 286(5):1621-1632.

Capaldi AP & Radford SE (1998) Kinetic studies of beta-sheet protein folding. Curr Opin Struct Biol 8(1):86-92.