Drug discovery using Drosophila models of human disease

One of the principal reasons for the high costs of drug development is the failure in the toxicity and/or efficacy stages when a drug is tested in vivo. Fly models can be used for screening entire libraries of compounds, for validating lead therapeutics quickly and effectively, and for testing drug toxicity and efficacy in vivo Read more about Drug discovery using Drosophila models of human disease[…]

Age-dependent alterations in RNA stress granules and cognition

Aging is the biggest risk factor for neurodegenerative disease and is garnering attention due to increased life expectancy. The ability of aging bodies to handle stress is diminished considerably by specific effects on multiple cellular processes including decreased translation. We have preliminary observations that RNA binding proteins associated with RNA stress granules and translation are Read more about Age-dependent alterations in RNA stress granules and cognition[…]

Metabolic dysregulation in ALS

Long-standing observations made in the clinic point to defects in metabolic regulation including abnormalities in glucose and lipid metabolism in ALS. Using our fruit fly model of ALS based on TDP-43 we have performed global metabolomics profiling and identified several significant metabolic changes consistent with alterations in cellular energetics. Specifically, increased pyruvate in both TDPWT Read more about Metabolic dysregulation in ALS[…]

RNA Processing in ALS

Several RNA binding proteins have been found in proteinaceous aggregates, a hallmark of neurodegeneration, which suggests that they are involved in the pathomechanism of disease. Additionally, some have been shown to harbor mutations causing amyotrophic lateral sclerosis (ALS) and/or related neurodegenerative diseases such as frontotemporal degeneration (FTD).  Among these, TDP-43 is linked to the vast Read more about RNA Processing in ALS[…]