Age-dependent alterations in RNA stress granules and cognition

Aging is the biggest risk factor for neurodegenerative disease and is garnering attention due to increased life expectancy. The ability of aging bodies to handle stress is diminished considerably by specific effects on multiple cellular processes including decreased translation. We have preliminary observations that RNA binding proteins associated with RNA stress granules and translation are altered in aging fly brains. In collaboration with Dr. Carol Barnes at University of Arizona we are beginning to explore correlations between RNA stress granules, aging and cognition in flies and rodents.