May 15, 2018


2021 Lehmkuhl, E. M., Loganathan, S., Alsop, E., Blythe, A. D., Kovalik, T., Mortimore, N. P., Barrameda, D., Kueth, C., Eck, R. J., Siddegowda, B. B., Joardar, A., Ball, H., Macias, M. E., Bowser, R., Van Keuren-Jensen, K., & Zarnescu, D. C. (2021). TDP-43 proteinopathy alters the ribosome association of multiple mRNAs including the glypican Dally-like protein (Dlp)/GPC6. Acta neuropathologica communications9(1), 52. DOI:10.1186/s40478-021-01148-z
2020 Daniela C. Zarnescu; Think globally, act locally: Centrosome-localized mRNAs ensure mitotic fidelity. J Cell Biol 7 December 2020; 219 (12): e202010172. DOI: 10.1083/jcb.202010172
2020 Nadine Bakkar, Alexander Starr, Benjamin E. Rabichow, Ileana Lorenzini, Zachary T. McEachin, Robert Kraft, Matthew Chaung, Sam Macklin-Isquierdo, Taylor Wingfield, Briggs Carhart, Nathan Zahler, Wen-Hsuan Chang, Gary J. Bassell, Alexandre Betourne, Nicholas Boulis, Samuel V. Alworth, Justin K. Ichida, Paul R. August, Daniela C. Zarnescu, Rita Sattler, Robert Bowser. The M1311V variant of ATP7A is associated with impaired trafficking and copper homeostasis in models of motor neuron disease,
Neurobiology of Disease 2021;149. DOI: 10.1016/j.nbd.2020.105228
2020 Loganathan S, Lehmkuhl E, Eck R, Zarnescu D. To Be or Not To Be…Toxic—Is RNA Association With TDP-43 Complexes Deleterious or Protective in Neurodegeneration? Frontiers in Molecular Biosciences 2020;6:154. DOI: 10.3389/fmolb.2019.00154
2019 Manzo E, Lorenzini I, Barrameda D, Conner A,  Barrows J, Starr A, Kovalik T, Shreiner D,
Joardar A, Lievens JC, Bowse R, Sattler R, Zarnescu D. Glycolysis upregulation is neuroprotective as a compensatory mechanism in ALS. eLife 2019;8:e45114. DOI: 10.7554/eLife.45114
2018 Ferro D, Yao S, Zarnescu D. Dynamic duo – FMRP and TDP-43: Regulating common targets, causing different diseases. Brain Research. 2018;1693(A):37-42. ISSN 0006-8993 DOI:10.1016/j.brainres.2018.04.034
2018 Chu M, Novak SM, Cover C, Wang AA, Chinyere IR, Juneman EB, Zarnescu DC, Wong PK, Gregorio CC. Increased Cardiac Arrhythmogenesis Associated with Gap Junction Remodeling with Upregulation of RNA-Binding Protein FXR1. Circulation. 137:605-618. PMID:29101288 DOI: 10.1161/CIRCULATIONAHA.117.028976 
2018 Lehmkuhl E.M., Zarnescu D.C. Lost in Translation: Evidence for Protein Synthesis Deficits in ALS/FTD and Related Neurodegenerative Diseases. Advances in Neurobiology. 20:283-301.DOI:10.1007/978-3-319-89689-2_11
2018 Manzo E, O’Conner AG, Barrows JM, Shreiner DD, Birchak GJ,  Zarnescu DC. Medium-chain fatty acids, beta-hydroxybutyric acid and genetic modulation of the carnitine shuttle are protective in a drosophila model of ALS based on TDP-43. Frontiers in Molecular Neuroscience. 11, 182. PMID: 29904341 DOI: 10.3389/fnmol.2018.00182
2018 Daniel SG, Russ AD, Guthridge KM, Raina AI, Estes PS, Parsons LM, Richardson HE, Schroeder JA, Zarnescu DC. miR-9a mediates the role of Lethal giant larvae as an epithelial growth inhibitor in Drosophila. Biology Open. PMID 29361610 DOI: 10.1242/bio.027391 
2018 Chou C-C, Zhang Y, Umoh ME, Vaughan SW, Lorenzini I, Liu F, Sayegh M, Donlin-Asp PG, Chen YH, Duong DM, Seyfried NT, Powers MA, Kukarm T, Hales CM, Gearing M, Cairns NJ,  Boylan KB, Dickson DW, Rademakers R, Zhang YJ, Petrucelli L, Sattler R, Zarnescu DC,  Glass JD, Rossoll W. TDP-43 pathology disrupts nuclear pore complexes and nucleocytoplasmic transport in ALS/FTD. Nat Neurosci. 2018 Feb; 21(2): 228–239. PMCID:PMC5800968 DOI: 10.1038/s41593-017-0047-3
2017 Daniel SG, Russ AD, Guthridge KM, Raina AI, Estes PS, Parsons LM, Richardson HE, Schroeder JA, Zarnescu DC. miR-9a mediates the role of Lethal giant larvae as an epithelial growth inhibitor in Drosophila. Biology Open. PMID 29233983 DOI: 10.1242/bio.027391
2017 Liu G, Coyne AN, Pei F, Vaughan S, Chaung M, Zarnescu DC, Buchan JR. Endocytosis regulates TDP-43 toxicity and turnover. Nature Communications. 8: 2092. PMID 29233983 DOI: 10.1038/s41467-017-02017-x 
2017 Coyne AN, Lorenzini I, Chou C-C, Torvund M, Rogers RS, Starr A, Zaepfel BL, Levy J, Johannesmeyer J, Schwartz J,  Nishimune H, Zinsmaier K, Rossoll W, Sattler R, Zarnescu DC. Post-transcriptional inhibition of Hsc70-4/HSPA8 expression leads to synaptic vesicle cycling defects in multiple models of ALS. Cell reports. 2017;21(1):110-125. DOI:10.1016/j.celrep.2017.09.028.
2017 Coyne AN, Zaepfel BL, Zarnescu DC. Failure to Deliver and Translate-New Insights into RNA Dysregulation in ALS. Frontiers in Cellular Neuroscience. 11: 243. PMID 28860970 DOI: 10.3389/fncel.2017.00243
2016 Coyne AN, Zarnescu DC. A Helping Hand: RNA-Binding Proteins Guide Gene-Binding Choices by Cohesin Complexes. Plos Genetics. 12: e1006419. PMID 27855157 DOI: 10.1371/journal.pgen.1006419
2015 Novak SM, Joardar A, Gregorio CC, Zarnescu DC. Regulation of Heart Rate in Drosophila via Fragile X Mental Retardation Protein. Plos One. 10: e0142836. PMID 26571124 DOI: 10.1371/journal.pone.0142836
2015 Coyne AN, Yamada SB, Siddegowda BB, Estes PS, Zaepfel BL, Johannesmeyer JS, Lockwood DB, Pham LT, Hart MP, Cassel JA, Freibaum B, Boehringer AV, Taylor JP, Reitz AB, Gitler AD, … Zarnescu DC, et al. Fragile X protein mitigates TDP-43 toxicity by remodeling RNA granules and restoring translation. Human Molecular Genetics. PMID 26385636 DOI: 10.1093/hmg/ddv389
2015 Chou CC, Alexeeva OM, Yamada S, Pribadi A, Zhang Y, Mo B, Williams KR, Zarnescu DC, Rossoll W. PABPN1 suppresses TDP-43 toxicity in ALS disease models. Human Molecular Genetics. PMID 26130692 DOI: 10.1093/hmg/ddv238
2015 Joardar A, Menzl J, Podolsky TC, Manzo E, Estes PS, Ashford S, Zarnescu DC. PPAR gamma activation is neuroprotective in a Drosophila model of ALS based on TDP-43. Human Molecular Genetics. 24: 1741-54. PMID 25432537 DOI: 10.1093/hmg/ddu587
2014 Coyne AN, Siddegowda BB, Estes PS, Johannesmeyer J, Kovalik T, Daniel SG, Pearson A, Bowser R, Zarnescu DC. Futsch/MAP1B mRNA is a translational target of TDP-43 and is neuroprotective in a Drosophila model of amyotrophic lateral sclerosis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 15962-74. PMID 25429138 DOI: 10.1523/JNEUROSCI.2526-14.2014
2013 Zarnescu DC, Gregorio CC. Fragile hearts: new insights into translational control in cardiac muscle. Trends in Cardiovascular Medicine. 23: 275-81. PMID 23582851 DOI: 10.1016/j.tcm.2013.03.003
2013 Estes PS, Daniel SG, McCallum AP, Boehringer AV, Sukhina AS, Zwick RA, Zarnescu DC. Motor neurons and glia exhibit specific individualized responses to TDP-43 expression in a Drosophila model of amyotrophic lateral sclerosis. Disease Models & Mechanisms. 6: 721-33. PMID 23471911 DOI: 10.1242/dmm.010710
2013 Morera AA, Coyne A, Zarnescu DC. Flies lies in motion: What drosophila can tell us about amyotrophic lateral sclerosis Drosophila Melanogaster Models of Motor Neuron Disease. 57-83. (Abstract)
2012 Russ A, Louderbough JM, Zarnescu D, Schroeder JA. Hugl1 and Hugl2 in mammary epithelial cells: polarity, proliferation, and differentiation. Plos One. 7: e47734. PMID 23110097 DOI: 10.1371/journal.pone.0047734
2012 Callan MA, Clements N, Ahrendt N, Zarnescu DC. Fragile X Protein is required for inhibition of insulin signaling and regulates glial-dependent neuroblast reactivation in the developing brain. Brain Research. 1462: 151-61. PMID 22513101 DOI: 10.1016/j.brainres.2012.03.042
2011 Whitman SA, Cover C, Yu L, Nelson DL, Zarnescu DC, Gregorio CC. Desmoplakin and talin2 are novel mRNA targets of fragile X-related protein-1 in cardiac muscle. Circulation Research. 109: 262-71. PMID 21659647 DOI: 10.1161/CIRCRESAHA.111.244244
2011 Estes PS, Boehringer A, Zwick R, Tang JE, Grigsby B, Zarnescu DC. Wild-type and A315T mutant TDP-43 exert differential neurotoxicity in a Drosophila model of ALS. Human Molecular Genetics. 20: 2308-21. PMID 21441568 DOI: 10.1093/hmg/ddr124
2011 Callan MA, Zarnescu DC. Heads-up: new roles for the fragile X mental retardation protein in neural stem and progenitor cells. Genesis (New York, N.Y. : 2000). 49: 424-40. PMID 21404421 DOI: 10.1002/dvg.20745
2010 Callan MA, Cabernard C, Heck J, Luois S, Doe CQ, Zarnescu DC. Fragile X protein controls neural stem cell proliferation in the Drosophila brain. Human Molecular Genetics. 19: 3068-79. PMID 20504994 DOI: 10.1093/hmg/ddq213
2010 Lee HG, Zarnescu DC, MacIver B, Thomas GH. The cell adhesion molecule Roughest depends on beta(Heavy)-spectrin during eye morphogenesis in Drosophila. Journal of Cell Science. 123: 277-85. PMID 20048344 DOI: 10.1242/jcs.056853
2010 Mounsef J, Karam L, Estes P, Zarnescu D. Shape analysis and classification of lgl-type and wild-type neurons 2010 Acm International Conference On Bioinformatics and Computational Biology, Acm-Bcb 2010. 362-365. DOI: 10.1145/1854776.1854830
2009 Zarnescu DC, Zinsmaier KE. Ferrying wingless across the synaptic cleft. Cell. 139: 229-31. PMID 19837027 DOI: 10.1016/j.cell.2009.09.032
2009 Cziko AM, McCann CT, Howlett IC, Barbee SA, Duncan RP, Luedemann R, Zarnescu D, Zinsmaier KE, Parker RR, Ramaswami M. Genetic modifiers of dFMR1 encode RNA granule components in Drosophila. Genetics. 182: 1051-60. PMID 19487564 DOI: 10.1534/genetics.109.103234
2009 Epstein AM, Bauer CR, Ho A, Bosco G, Zarnescu DC. Drosophila Fragile X protein controls cellular proliferation by regulating cbl levels in the ovary. Developmental Biology. 330: 83-92. PMID 19306863 DOI: 10.1016/j.ydbio.2009.03.011
2008 Bauer CR, Epstein AM, Sweeney SJ, Zarnescu DC, Bosco G. Genetic and systems level analysis of Drosophila sticky/citron kinase and dFmr1 mutants reveals common regulation of genetic networks. Bmc Systems Biology. 2: 101. PMID 19032789 DOI: 10.1186/1752-0509-2-101
2008 Estes PS, O’Shea M, Clasen S, Zarnescu DC. Fragile X protein controls the efficacy of mRNA transport in Drosophila neurons. Molecular and Cellular Neurosciences. 39: 170-9. PMID 18655836 DOI: 10.1016/j.mcn.2008.06.012
2008 Chang S, Bray SM, Li Z, Zarnescu DC, He C, Jin P, Warren ST. Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila. Nature Chemical Biology. 4: 256-63. PMID 18327252 DOI: 10.1038/nchembio.78
2005 Zarnescu DC, Shan G, Warren ST, Jin P. Come FLY with us: toward understanding fragile X syndrome. Genes, Brain, and Behavior. 4: 385-92. PMID 16098136 DOI: 10.1111/j.1601-183X.2005.00136.x
2005 Zarnescu DC, Jin P, Betschinger J, Nakamoto M, Wang Y, Dockendorff TC, Feng Y, Jongens TA, Sisson JC, Knoblich JA, Warren ST, Moses K. Fragile X protein functions with lgl and the par complex in flies and mice. Developmental Cell. 8: 43-52. PMID 15621528 DOI: 10.1016/j.devcel.2004.10.020
2004 Zarnescu DC, Moses K. Born again at the synapse: a new function for the anaphase promoting complex/cyclosome. Developmental Cell. 7: 777-8. PMID 15572119 DOI: 10.1016/j.devcel.2004.11.011
2004 Jin P, Zarnescu DC, Ceman S, Nakamoto M, Mowrey J, Jongens TA, Nelson DL, Moses K, Warren ST. Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway. Nature Neuroscience. 7: 113-7. PMID 14703574 DOI: 10.1038/nn1174
2003 Jin P, Zarnescu DC, Zhang F, Pearson CE, Lucchesi JC, Moses K, Warren ST. RNA-mediated neurodegeneration caused by the fragile X premutation rCGG repeats in Drosophila. Neuron. 39: 739-47. PMID 12948442 DOI: 10.1016/S0896-6273(03)00533-6
2002 Médina E, Williams J, Klipfell E, Zarnescu D, Thomas G, Bivic AL. Crumbs interacts with moesin and βHeavy-spectrin in the apical membrane skeleton of Drosophila. Journal of Cell Biology. 158: 941-951. PMID 12213838 DOI: 10.1083/jcb.200203080
1999 Zarnescu DC, Thomas GH. Apical spectrin is essential for epithelial morphogenesis but not apicobasal polarity in Drosophila. The Journal of Cell Biology. 146: 1075-86. PMID 10477760 DOI: 10.1083/jcb.146.5.1075
1998 Thomas GH, Zarnescu DC, Juedes AE, Bales MA, Londergan A, Korte CC, Kiehart DP. Drosophila betaHeavy-spectrin is essential for development and contributes to specific cell fates in the eye. Development (Cambridge, England). 125: 2125-34. PMID 9570776