April 18, 2019

Research

RNA targets of TDP-43
In addition to searching for protein partners, we have sought to identify mRNA targets of TDP-43 in neurons.  We recently
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RNA Processing in ALS
Several RNA binding proteins have been found in proteinaceous aggregates, a hallmark of neurodegeneration, which suggests that they are involved
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Metabolic dysregulation in ALS
Long-standing observations made in the clinic point to defects in metabolic regulation including abnormalities in glucose and lipid metabolism in
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Drug discovery using Drosophila models of human disease
One of the principal reasons for the high costs of drug development is the failure in the toxicity and/or efficacy
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Age-dependent alterations in RNA stress granules and cognition
Aging is the biggest risk factor for neurodegenerative disease and is garnering attention due to increased life expectancy. The ability
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