RNA targets of TDP-43
In addition to searching for protein partners, we have sought to identify mRNA targets of TDP-43 in neurons. We recentlyRead more.
RNA Processing in ALS
Several RNA binding proteins have been found in proteinaceous aggregates, a hallmark of neurodegeneration, which suggests that they are involvedRead more.
Metabolic dysregulation in ALS
Long-standing observations made in the clinic point to defects in metabolic regulation including abnormalities in glucose and lipid metabolism inRead more.
Drug discovery using Drosophila models of human disease
One of the principal reasons for the high costs of drug development is the failure in the toxicity and/or efficacyRead more.
Age-dependent alterations in RNA stress granules and cognition
Aging is the biggest risk factor for neurodegenerative disease and is garnering attention due to increased life expectancy. The abilityRead more.