We are happy to have been part of an interesting study led by the Kraft laboratory (U of A) on the role of Edc3 phosphorylation in P-body dynamics and the pathology of prostate and lung cancer. This is also the first description of our mRNP granule purification method, which we hope to share in more detail in the near future.
Congrats to Nikita for her co-authorship!
We also contributed to an extensive resource (Guidelines for the use and interpretation of assays for monitoring autophagy) lead by Dan Klionsky, which is an invaluable resource in the field.
Congrats to Aaron for his co-authorship!
Nikita has published a 1st author paper in the journal Biomolecules, concerning the role of SGs in TDP-43 phenotypes, using yeast and human cell studies. Congrats Nikita! Thanks to our collaborators also (Ivanov and Bolger labs).
Hearty congratulations to Nikita Fernandes who graduated in August 2020 (with two first author research manuscripts, a co-authorship and two first author reviews to her name). Not too shabby! We look forward to seeing what the future brings for you!
Very happy to announce a first author paper for Nikita in the journal Nucleic Acids Research. We describe an interesting new mechanism by which P-bodies in yeast are scaffolded by an mRNA 3’UTR via a “cis-translation” dependent mechanism. Congrats Nikita!
Yay! A co-first author paper in Molecular and Cellular Biology for Guangbo and Aaron, with significant contributions from Amanda, Fen, Eman and Allison also. A follow up to our work on the role of endocytosis in turnover of aggregation-prone RNA binding proteins implicated in ALS pathology. Well done folks!
Nichole, in collaboration with the Capaldi lab, has published a letter in the journal RNA detailing various methods for assessing mRNA decay, and their effects on stress signaling pathways. Nice job guys!
A momentous day in the lab – our first grad student, Nichole, successfully defended her Ph.D on the regulation of cytoplasmic mRNA decay. More pictures to follow but for now, suffice to say – we’re all very proud of you Nichole, and look forward to seeing what the future brings!
We have a couple of papers in the works, both of which you can preview on Biorxiv at the links below:
Cdc48/VCP and endocytosis regulate TDP-43 and FUS toxicity and turnover
RPS28B mRNA acts as a scaffold promoting cis-translational interaction of proteins driving P-body assembly
We’re lucky to have Amanda Warner in lab, already a Beckman Scholar, who this Spring earned an additional 4 scholarships and 2 awards:
1. Travel grant from BECUR (Biological, engineering, and chemical undergraduate research conference) to the Experimental Biology Conference 2020
2. Danny Brower Memorial Scholarship from MCB Department-to support student scientists
3. Excellence Awards in Biological Sciences from CBC Department-for lab supplies to support student research
4. Michael A. Wells Memorial Scholarship from CBC Department-for conference fees and lab supplies to support science communication
5. Dr. Thomas and Candace Grogan Scholarship from CBC Department-for supporting college expenses for students in science with financial need
6. Klaiman Memorial Scholarship from College of Science-for supporting college education for females in the STEM field with financial need
Many congratulations Amanda, and thank you to all of the above organizations for helping Amanda conduct research in our lab.
Woohoo! Aaron has been awarded a 3 year Graduate scholarship from NSF. Many thanks to NSF for supporting Aaron’s work on endocytosis and it’s effect on TDP-43 and FUS clearance.
Awesome job Aaron!